Synthetic Organic Chemistry
Synthesis of lead molecules
(generally defined as MW<900)
Understand the relationship between the structure of the connection and the mechanism of its biological functioning
Chemical Biology &
Computational (Bio)chemistry Tools
Target inhibition ability studies
Discovery and development of molecular entities
The manipulation and interrogation of biological systems using natural or synthetic molecules
The TuYuN Research Group (TRG) is currently involved with active investigations into a variety of multiple areas of research including the organic synthesis, computational chemistry, chemical biology, and bioorganic chemistry. We are interested in the design, synthesis, and characterization of functional organic molecules with tailored properties. While the main part of our research involves synthesis of new lead small organic molecules, we also use the advantage of computational methods to predict the properties of these lead organic molecules. Our design is based on the anticancer lead molecules for the site-specific activation in cancer cell lines, mode of actions; additionally, antimicrobial lead molecules.
Specifically, efforts are being focused on the design, synthesis, and evaluation of anticancer lead molecules for the treatment of advanced leukemia, breast, and prostate cancers, and the discovery of small molecule inhibitors of interactions with promising biological profiles. Exciting outgrowths of these two main areas are the structural product collections. These valuable product collections may find a new host in the assays of our biological collaborators and may start their new journey.
Extensive collaboration with other nationally and internationally research groups is a feature of our work. The collaborative research leads to extensive research output in terms of publications and plays an important role in facilitating the pharmaceutical sector.